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This led to the conclusion that IMPase is required for the correct localization of synaptic protein components. The egl-8 gene encodes a homolog of phospholipase Cβ (PLCβ), an enzyme that cleaves PIP2.

Silverthorn, D. (2012) Human Physiology: An Integrated Approach, 6th edition. From Chapter 1 of Human Physiology: An Integrated Approach, Sixth Edition. Dee Unglaub Silverthorn. Description, The College Board, 2010. http://apcentral.collegeboard.com/apc/public/repository/ap-biology-course-description.pdf.

They are still widely used today, though many types of bacteria have developed resistance following extensive use.

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